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KMID : 0385219990090010025
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Korean Journal of Gerontology
1999 Volume.9 No. 1 p.25 ~ p.30
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Effect of Flavonoids on Metal-Catalyzed Glyoxal Formation from Glucose
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Song Dong-Up
So Keum-Young
Joung Young-Do
Yang Sung-Yeul
Ahn Bong-Whan
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Abstract
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The inhibitory effects of flavonoids on glyoxal formation from glucose by metal-catalyzed oxidation (MCO) systems were examined. The flavonoids tested were as follows: EGCG, ECG, EGC, EC, myricetin, kaempferol, quercetin, silymarin, luteolin, hesperidin, naringenin, apigenin and genistein. And two MCO systems,0.3 μM FeSO₄/1 mM ascorbate and 0.1 μM CuSO₄/1 mM ascorbate, were used since, at these concentrations, the MCO systems were found to stimulate maximally the glyoxal formation from glucose. The results were as follows: 1. EGCG, ECG, myricetin, kaempferol, quercetin, silymarin, and luteolin could inhibit the glyoxal formation by CuSO₄/ascorbate, with values of 0.6-25 μM. In particular, EGCG, ECG and myricetin could inhibit very effectively the glyoxal formation by CuSO₄/ascorbate, with IC50 values less than 1 μM. 2. EGCG, ECG, and myricetin could inhibit the glyoxal formation by FeSO₄/ascorbate, with IC50 valuers of 6.5 -51 μm. 3. Flavouoids inhibited more potently the glyoxal formation by CuSO₄/ascorbate than that by FeSO₄/ascorbate. These results suggest that some flavonoids such as EGCG, ECG, and myricetin may be useful inhibitors of glucose oxidation occurring in vivo.
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KEYWORD
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Flavonoids, Glyoxal, Dicarbonyl, Glucose oxidation, Metal-catalyzed oxidation(MCO), AGE
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